The Center for Stem Cell & Organoid Medicine (CuSTOM), in collaboration with the Division of Nephrology, has an excellent opportunity for a talented researcher to join a highly collaborative team of research scientists investigating human kidney development, innovating strategies for deriving kidney tissues and organoids from pluripotent stem cells, and applying these models to investigation of human kidney disease.
About the role: The McCracken lab at Cincinnati Children's Hospital Medical Center investigates kidney development using human pluripotent stem cells (hPSCs), organoids, and mouse models. The goals of the laboratory include the elucidation of basic embryologic mechanisms, the application of in vitro models to understanding human kidney development and congenital defects, and engineering of complex tissue models for kidney regenerative medicine. The lab uses a combination of stem cell biology, gene editing techniques, single cell genomics, and tissue engineering to address these important goals. Recent work has enabled the differentiation of branching epithelial organoids that represent the developing collecting system of the kidney, which the lab uses to understand how the collecting system is built during organogenesis. This platform also provides tissues to model renal physiology and gain insights into disease pathogenesis, including congenital kidney anomalies observed in newborns. We have exciting opportunities for a talented researcher to lead a project in these areas using state-of-the-art technologies and establish themselves in the growing field of kidney regenerative medicine. The successful applicant will generate data leading to high quality publications, as well as apply for competitive grant applications as part of their career development.
MAJOR DUTIES AND RESPONSIBILITIES: ??? Design, execute, and record laboratory experiments, and analyze the data. ??? Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department. ??? Present research at laboratory meetings, journal clubs, seminars, and meetings. ??? Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants. ??? Maintain currency in field through continuing education, literature, and seminars. ??? Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures. ??? Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
REQUIRED ??? Ph.D. in related discipline, MD, or equivalent required.
You will have a PhD in developmental biology, molecular biology, genetics, biomedical engineering, or a related discipline, evidenced by a strong publication record, including first author papers. You will have a vision and passion for kidney development and tissue engineering and discovery research that will be a major advancement in the field. You enjoy staying abreast of new genomic and cellular technologies, methodologies, and institute strategies to help identify future research opportunities and contributing to grant writing. You adopt an open and collaborative approach to scientific research, value a positive team culture, and are looking to build on your developing management and leadership skills.
??? Demonstrated experience in the design, analysis, and interpretation of experiments. ??? A growing scientific independence with an ability to solve problems and a desire to make a personal contribution to scientific research. ??? Line-management or supervisory experience, with a strong desire to further develop leadership skills. ??? An attention to detail and ability to work to tight timelines. ??? An ability to communicate effectively with scientists from multiple disciplines, including computational and clinical.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.